Date of Award
8-2024
Document Type
Campus Access Thesis
Degree Name
Master of Science (MS)
Department
Chemistry/Organic Chemistry
First Advisor
Wei Zhang
Second Advisor
Bela Torok
Third Advisor
Jason Evans
Abstract
The GBB-3CR is highly efficient in synthesizing the N-bridgehead heterobicyclic core associated with biologically interested compounds. This work presents a new method for the synthesis of the 3,5-dihydro-4H-1,2a1,3-triazaacenaphthylen-4-one scaffold by sequential GBB/N-Acylation/Radical cyclization reactions. A series of etherate reactants were used for the radical addition and cyclization reactions. The addition of ZnCl2 was found critical during the radical reaction. The substrate scope was demonstrated in the synthesis of 19 functionalized heterocyclic compounds.
Recommended Citation
Zanuy, Abel, "Multicomponent and Sequential Radical Reactions for the Synthesis of Functionalized Heterocyclic Compounds" (2024). Graduate Masters Theses. 855.
https://scholarworks.umb.edu/masters_theses/855
Comments
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