Date of Award

8-2024

Document Type

Campus Access Thesis

Degree Name

Master of Science (MS)

Department

Exercise and Health Science

First Advisor

Huimin Yan

Second Advisor

Tracy Baynard

Third Advisor

Christina Dieli-Conwright, Richard Viskochil

Abstract

Background: Black and Hispanic breast cancer patients are especially vulnerable to chemotherapy-induced toxicity that may increase cardiovascular risk. Hemodynamics, predictive of future cardiovascular events, have been shown to be compromised in White cancer patients during chemotherapy. However, the potential alterations in hemodynamics during acute peak aerobic exercise, which might uncover cardiovascular changes not observable at rest, have not been investigated in cancer patients, nor specifically in Black and Hispanic breast cancer patients receiving chemotherapy. Purpose: To investigate hemodynamic recovery after peak aerobic exercise in Black and Hispanic breast cancer patients undergoing chemotherapy Methods: Seven Black and Hispanic breast cancer patients receiving chemotherapy completed a peak cardiopulmonary exercise test (CPET) on a cycle ergometer. Hemodynamic measures were taken at baseline, 7-min, and 10-min after CPET. Brachial blood pressure (BP), aortic BP, augmentation pressure (AP), augmentation index at 75 beats per min (AIx@75), forward pressure (Pf), and backward pressure were assessed using the non-invasive, oscillometric Mobil-O-Graph (IEM GmbH, Stolberg, Germany). One-way repeated measures ANOVA was used to test for potential differences across time. Results: Brachial and aortic pulse pressure (PP) decreased significantly from 7-min to 10-min after CPET (p < 0.05). AP and Pf decreased significantly from 7-min to 10-min after CPET (p < 0.05). Changes in AIx@75 approached significance (p = 0.055). Conclusion: Black and Hispanic breast cancer patients undergoing chemotherapy exhibited reductions in PP, AP, and Pf during recovery from CPET. Further research is warranted to identify mechanisms that underlie the hemodynamic responses of breast cancer patients undergoing chemotherapy.

Comments

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Additional Files

James Cannon MS Thesis Summer 2024 Signatory Page 7_17 final.pdf (253 kB)

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