Date of Award

Fall 12-2023

Document Type

Campus Access Thesis

Degree Name

Master of Science (MS)



First Advisor

Wei Zhang

Second Advisor

Hannah Sevian

Third Advisor

Bela Torok


1,3-Dipolar [3+2] cycloadditions are an important class of reactions for making poly-heterocyclic ring scaffolds with potential biological activities. Presented in this thesis is a reaction sequence of three-component 1,3-dipolar cycloaddition of a non-stabilized azomethine ylides, formed by decarboxylative condensation of α-amino acids, for making pyrrolidine-based adduct followed by the aza-Wittig reaction of for the synthesis of poly-heterocyclic products. In this work, polymer supported triphenylphosphine was used as a phosphine source for the aza-Wittig reaction to minimize the amount of waste and simplify the purification process.


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