Date of Award
12-2023
Document Type
Campus Access Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Wei Zhang
Second Advisor
Hannah Sevian
Third Advisor
Bela Torok
Abstract
1,3-Dipolar [3+2] cycloadditions are an important class of reactions for making poly-heterocyclic ring scaffolds with potential biological activities. Presented in this thesis is a reaction sequence of three-component 1,3-dipolar cycloaddition of a non-stabilized azomethine ylides, formed by decarboxylative condensation of α-amino acids, for making pyrrolidine-based adduct followed by the aza-Wittig reaction of for the synthesis of poly-heterocyclic products. In this work, polymer supported triphenylphosphine was used as a phosphine source for the aza-Wittig reaction to minimize the amount of waste and simplify the purification process.
Recommended Citation
Price, Lee A., "Synthesis of Novel Fused-Heterocyclic Scaffold Via Diastereoselective Decarboxylative [3+2] Cycloadditions and Aza-Wittig Reactions" (2023). Graduate Masters Theses. 807.
https://scholarworks.umb.edu/masters_theses/807