Date of Award
Open Access Thesis
Master of Science (MS)
1,3-Dipolar [3+2] cycloadditions are an important class of reactions for making poly-heterocyclic ring scaffolds with potential biological activities. Presented in this thesis is a reaction sequence of three-component 1,3-dipolar cycloaddition of a non-stabilized azomethine ylides, formed by decarboxylative condensation of α-amino acids, for making pyrrolidine-based adduct followed by the aza-Wittig reaction of for the synthesis of poly-heterocyclic products. In this work, polymer supported triphenylphosphine was used as a phosphine source for the aza-Wittig reaction to minimize the amount of waste and simplify the purification process.
Price, Lee A., "Synthesis of Novel Fused-Heterocyclic Scaffold Via Diastereoselective Decarboxylative [3+2] Cycloadditions and Aza-Wittig Reactions" (2023). Graduate Masters Theses. 807.