Date of Award

12-31-2013

Document Type

Open Access Thesis

Degree Name

Master of Arts (MA)

Department

Clinical Psychology

First Advisor

S. Tiffany Donaldson

Second Advisor

Dorothea J. Jenkins

Third Advisor

Alice S. Carter

Abstract

Term neonates with hypoxic-ischemic (HI) injury are at risk for devastating neurological sequelae. The objective of this study is to determine if altering the early environment for maternal care-taking impacts the immediate and long-term sequelae of HI offspring. The Rice-Vannucci model was used to induce HI in postnatal day (PND) 7 Long-Evans pups. Litters were assigned to a closed nest (CN) or normal standard housing (SH) condition. Neurobehavioral development, cognitive ability, and stress response were assessed to establish any benefits of the CN condition. Finally, postmortem brain tissue was analyzed for morphometric markers of injury.

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