Date of Award


Document Type

Campus Access Thesis

Degree Name

Master of Science (MS)


Exercise and Health Science

First Advisor

Huimin Yan

Second Advisor

Rachel Drew

Third Advisor

Tongjian You


Wave intensity analysis is a hemodynamic index that assesses the working interaction between the heart and the arterial system. There is evidence of differential ventricular and vascular responses following exercise in women and men. Recent findings also suggest that histamine receptor blockade may affect carotid arterial vessel vasodilation.

Purpose: The purpose of this secondary analysis study was to explore the effects of sex and histamine receptor blockade on carotid wave intensity analysis at rest and following an acute bout of aerobic exercise.

Methods: Forty-nine healthy participants (men: n=23; women: n=26; 22 ± 1 years) were randomly assigned to histamine receptor blockade or control placebo condition, with the order randomized and underwent carotid wave intensity analysis measurements at rest and at 30, 60, and 90 minutes following 45-minute moderate intensity treadmill exercise. The effects of condition (blockade vs. control) and sex at rest were analyzed by two-way repeated measures ANOVA. The effects of time, condition, and sex were analyzed by three-way repeated measures ANOVA.

Results: Negative area, which is associated with reflected waves from the cerebrovasculature, was higher in men compared to women at rest and during recovery from exercise (p

Conclusions: Young, healthy men have higher cerebrovascular resistance compared to women, which may contribute to the higher risk of stroke in men. In addition, histamine receptors may have different roles in mediating cardiac contractility in men and women. Finally, ventricular-coupling responses are sensitive to different physiological stimulus and the exercise modes and durations affect the hemodynamic responses.


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