Date of Award
8-31-2026
Document Type
Open Access Thesis
Degree Name
Master of Science (MS)
Department
Physics, Applied
First Advisor
Jonathan Celli
Abstract
Photodynamic therapy (PDT) is a minimally invasive treatment that uses light-activated photosensitizers to selectively destroy diseased tissue through the generation of reactive oxygen species. However, conventional in vitro models often fail to accurately reproduce the pharmacokinetics of photosensitizer accumulation and clearance observed in vivo. This study investigated protoporphyrin IX (PpIX) accumulation following 5-aminolevulinic acid (ALA) exposure under physiologically relevant conditions using two-dimensional (2D) monolayers and three-dimensional (3D) spheroids. By comparing continuous ALA exposure with transient exposure followed by ALA washout, this work provides a more biologically relevant framework for studying PpIX kinetics and optimizing photodynamic therapy.
Recommended Citation
Melebor, Priscilla, "Modeling Kinetics of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Accumulation for Optimal Photodynamic Therapy" (2026). Graduate Masters Theses. 968.
https://scholarworks.umb.edu/masters_theses/968
Included in
Atomic, Molecular and Optical Physics Commons, Biophysics Commons, Optics Commons, Other Physics Commons
Comments
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