Date of Award
6-2011
Document Type
Campus Access Thesis
Degree Name
Master of Science (MS)
Department
Biology
First Advisor
Alexey Veraksa
Second Advisor
Katherine E. Gibson
Third Advisor
Linda Huang
Abstract
Notch is a transmembrane receptor that plays a crucial role in cell fate determination during development. Previous work identified Kurtz (Krz), a Drosophila homolog of mammalian β-arrestins, as a component of the Notch protein interaction network. In this study, I extended the characterization of the Notch and Krz interaction networks. For Notch, I undertook a novel in vivo approach that will allow me to follow the dynamics of Notch signaling and its interactions by expressing tagged Notch receptor at its endogenous level. Investigation of the Krz interacting proteins revealed a surprising connection with Ulp1 which is involved in regulation of SUMO conjugation.
Recommended Citation
Basu, Sukanya, "Investigating Notch and Kurtz Interaction Networks" (2011). Graduate Masters Theses. 38.
https://scholarworks.umb.edu/masters_theses/38
Comments
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